CNX Vagus Nerve

Authors

Affiliations

Nathaniel Yomogida, B.S., SPT

Doctor of Physical Therapy

B.S. in Kinesiology

Chloë Kerstein, B.S., SPT

Doctor of Physical Therapy

B.A. in Neuroscience

Clinical Significance

Parkinson’s Disease

Furthermore, it was observed that vagal nerve sections prevented the intestine-to-brain propagation of fibrils and neurodegeneration [11]. Thus, the vagus nerve seems to serve as the conduit for α-syn propagation from the gut to the CNS¹

Dysfunction

Syndromes involving CN9-12 (CN IX-CNXII) from Table 13-1²

Syndrome (Eponym)	Nerves Affected	Location of Lesion
Collet-Sicard	CN IX, X, XI, XII2	Retroparotid space usually Lesion may be intracranial or extracranial2
Villaret	CN IX, X, XI, XII Plus the sympathetic chain CN VII is occassionally involved2	Retroparotid or retropharyngeal space2
Schmidt	CN IX & X2	Usually intracranial before nerve fibers leave the skull; Occassionally inferior margin of jugular foramen2
Jackson	CN IX, X, & XI2	May be intraparenchymal (medulla); Usually intracranial before nerve fibers leave the skull2
Tapia	CN X & XII (CNXI and the sympathetic chain are occassionally involved)2	Usually high in the neck2
Garcin (hemibase syndrome)	All Cranial Nerves on one side (often incomplete)2	Often infiltrative; Arising from base of skull (especially nasopharyngeal carcinoma)2

Interventions

Vagal Nerve stimulation (non-invasive)

References

1.

Montalbán-Rodríguez A, Abalo R, López-Gómez L. From the Gut to the Brain: The Role of Enteric Glial Cells and Their Involvement in the Pathogenesis of Parkinson’s Disease. International Journal of Molecular Sciences. 2024;25(2):1294. doi:10.3390/ijms25021294

2.

Brazis PW, Masdeu JC, Biller J. Localization in Clinical Neurology. 8th ed. Wolters Kluwer Health; 2022.